A four-year-old girl from Kirksville was seriously injured in a crash that happened early Monday morning on US 36, two miles east of Monroe City. The Highway patrol says 31 year old James Fisher was driving a Freighliner Cascadia and ran off the right side of the roadway and overturned. Fisher was not wearing a seat belt and suffered minor injuries. The child was transported by air services to University medical center. The Freightliner was totaled.